Center List of Publications
Center list of publications Heading link
The following is a list of center publications from 1999 to the present. If you wish to jump directly to a specific year, use the links below.
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2019 (5)
Bolton J, Dunlap T, Hajirahimkhan A, Mbachu O, Chen SN, Chadwick L, Nikolic D, van Breemen R, Pauli G, Dietz B. The multiple biological targets of hops and bioactive compounds. Chemical Research in Toxicology. 2019;32(2):222-233
McAlpine J, Chen SN, Kutateladze A, MacMillan J, Appendino G, Barison A, Beniddir M, Biavatti M, Bluml S, Boufridi A, Butler M, Capon R, Choi Y, Coppage D, Crews P, Crimmins M, Csete M, Dewapriva P, Egan J, Garson M, Genta-Jouve G, Gerwick W, Gross H, Harper M, Hermanto P, Hook J, Hunter L, Jeannerat D, Ji NY, Johnson T, Kingston D, Koshino H, Lee HW, Lewin G, Li J, Kinington R, Liu M, McPhail K, Molinski T, Moore B, Nam JW, Neupane R, Niemitz M, Nuzillard JM, Oberlies N, Ocampos F, Pan G, Quinn R, Reddy D, Renault JH, Rivera-Chávez J, Robien W, Saunders C, Schmidt T, Seger C, Shen B, Steinbeck C, Stuppner H, Sturm S, Taglialatela-Scafati O, Tantillo D, Verpoorte R, Wang B, Williams C, Willians P, Wist J, Yue JM, Zhang C, Xu Z, Simmler C, Lankin D, Bisson J, Pauli G. The value of universally available raw NMR data for transparency, reproducibility, and integrity in Natural Products Research. Natural Products Reports. 2019;36:35-107
Bolton JL, Dunlap TL, Hajirahimkhan A, Pauli GF, Chen SN, Nikolic D, van Breemen RB, Dietz BM. The multiple biological targets of hops and bioactive compounds. Chem. Res. Toxicol. (2019) in press [Cover Issue] doi: 10.1021/acs.chemrestox.8b00345
AbouZid SF, Ahmed HS, Abd El Mageed A-EMA, Moawad AS, Owis AI, Chen S-N, Nachtergael A, McAlpine JB, Friesen JB, Pauli GF. Linear regression analysis of silychristin A, silybin A and silybin B contents in Silybum marianum. Nat Prod Res. 2019:in press. doi: 10.1080/14786419.2018.1527838.
Wang S, Dunlap TL, Huang L, Liu Y, Simmler C, Lantvit DD, Crosby J, Howell CE, Dong H, Chen S-N, Pauli GF, van Breemen RB, Dietz BM, Bolton JL. Evidence for Chemopreventive and resilience activity of licorice: Glycyrrhiza glabra and G. inflata extracts modulate estrogen metabolism in ACI rats. Cancer Prevention Research. 2019:in press. doi: 10.1158/1940-6207.CAPR-18-0178.
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2018 (12)
Rue EA, Rush MD, van Breemen RB. Procyanidins: a comprehensive review encompassing strucure elucidation via mass spectrometry. Phytochem. Rev. 2018;17:1-16
Wang S, Dunlap T, Huang L, Liu Y, Simmler C, Lantvit D, Crosby J, Howell C, Dong H, Chen SN, Pauli G, van Breemen R, Dietz B, Bolton J. Evidence for chemopreventive and resilience activity of licorice: Glycyrrhiza glabra and G. inflata extracts modulate extrogen metabolism in ACI rats. Cancer Prevention Research. 2018;11(12):819-830
Abouzid S, Ahmed H, Abd EI Mageed AE, Moawad A, Owis A, Chen SN, Nachtergael A, McAlpine J, Friesen J, Pauli G. Linear regression analysis of silychristin A, silybin A and silybin B contents in Silybum Marianum. Natural Products Research. 2018;29:1-6
Phansalkar R, Nam JW, Chen SN, McAlpine J, Leme A, Aydin B, Beran-Russo AK, Pauli G. Centrifugal partition chromatograpy enables selective enrichment of trimeric and tetrameric proanthocyanidins for biomaterial development. Journal of Chromatography A. 2018;1535:55-62
Choules M, Klein L, Lankin D, McAlpine J, Chi SH, Cheng J, Lee H, Suh JW, Jaki B, Franzblau S, Pauli G. E Residual Complexity Does Impact Organic Chemistry and Drug Discovery: The Case of Rufomyazine and Rufomycin. Journal of Organic Chemistry. 2018;83:6664-6672
Wang S, Dunlap TL, Huang L, Liu Y, Simmler C, Lantivit D, Dong H, Dietz BM, Chen SN, Pauli GF, van Breemen RB, Bolton, JL. Licorice (Glycyrrhiza inflata) and bioactive compound licochalcone A down-regulate estrogen oxidative metabolism in vivo. Cancer Prevention Res. 2018;11:819-829
Bolton JL, Dunlap T, Dietz BM. Formation and biological targets of botanical o-quinones. Food Chem. Toxicol. 2018;120,700–707
Simmler C, Graham JG, Chen S-N, Pauli GF. Integrated analytical assets aid botanical authenticity and adulteration management. Fitoterapia. 2018;129:401-14. doi: https://doi.org/10.1016/j.fitote.2017.11.017
Liu Y, Zhang Y, Chen S-N, Friesen JB, Nikolić D, Choules MP, McAlpine JB, Lankin DC, Gemeinhart RA, Pauli GF. The influence of natural deep eutectic solvents on bioactive natural products: studying interactions between a hydrogel model and Schisandra chinensis metabolites. Fitoterapia. 2018;127:212-9. doi: https://doi.org/10.1016/j.fitote.2018.02.024
Liu Y, Friesen JB, McAlpine JB, Lankin DC, Chen S-N, Pauli GF. Natural Deep Eutectic Solvents: Properties, Applications, and Perspectives. J Nat Prod. 2018;81(3):679-90. doi: 10.1021/acs.jnatprod.7b00945
Hajirahimkhan A, Mbachu O, Simmler C, Ellis SG, Dong H, Nikolic D, Lankin DC, van Breemen RB, Chen S-N, Pauli GF, Dietz BM, Bolton JL. Estrogen Receptor (ER) Subtype Selectivity Identifies 8-Prenylapigenin as an ERβ Agonist from Glycyrrhiza inflata and Highlights the Importance of Chemical and Biological Authentication. J Nat Prod. 2018;81(4):966-75. doi: 10.1021/acs.jnatprod.7b01070
Fan Q, Liu Y, Kulakowski D, Chen S, Friesen JB, Pauli GF, Song Q. Countercurrent separation assisted identification of two mammalian steroid hormones in Vitex negundo. J Chromatogr A. 2018;1553:108-15. doi: https://doi.org/10.1016/j.chroma.2018.04.033
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2017 (16)
Bolton JL, Dunlap T. Formation and Biological Targets of Quinones: Cytotoxic versus Cytoprotective Effects. Chem Res Toxicol. 2017; 30:13-37. [Project 2/ Core C]
Rush MD, Walker EM, Prehna G, Burton T, van Breemen RB. Development of a Magnetic Microbead Affinity Selection Screen (MagMASS) Using Mass Spectrometry for Ligands to the Retinoid X Receptor-α. J Am Soc Mass Spectrom. 2017; 28:479-485. [Project 3/ Core D]
Phansalkar RS, Simmler C, Bisson J, Chen SN, Lankin DC, McAlpine JB, Niemitz M, Pauli GF. Evolution of Quantitative Measures in NMR: Quantum Mechanical qHNMR Advances Chemical Standardization of a Red Clover (Trifolium pratense) Extract. J Nat Prod. 2017; 80:634-647. [Project 1/ Core B]
Rue EA, Rush MD, van Breemen RB. Procyanidins: a comprehensive review encompassing structure elucidation via mass spectrometry. Phytochem. Rev. May 2017. [Project 3/ Core D]
AbouZid SF, Ahmed HS, Moawad AS, Owis AI, Chen SN, Nachtergael A, McAlpine JB, Brent Friesen J, Pauli GF. Chemotaxonomic and biosynthetic relationships between flavonolignans produced by Silybum marianum populations. Fitoterapia. 2017; 119:175-184. [Project 1/ Core B]
Liu Y, Friesen JB, Grzelak EM, Fan Q, Tang T, Durić K, Jaki BU, McAlpine JB, Franzblau SG, Chen SN, Pauli GF. Sweet spot matching: A thin-layer chromatography-based countercurrent solvent system selection strategy. J Chromatogr A. 2017; 1504:46-54. [Project 1/ Core B]
Li G, Simmler C, Chen L, Nikolic D, Chen SN, Pauli GF, van Breemen RB. Cytochrome P450 inhibition by three licorice species and fourteen licorice constituents. Eur J Pharm Sci. 2017; 109:182-190. [Project 1/ Core B/ Project 3/ Core D]
Dietz BM, Chen SN, Alvarenga RFR, Dong H, Nikolić D, Biendl M, van Breemen RB, Bolton JL, and Pauli GF. DESIGNER Extracts as Tools to Balance Estrogenic and Chemopreventive Activities of Botanicals for Women’s Health. Journal of Natural Products 2017; 80: 2284-2294. [Project 1/ Core B/ Project 2/ Core C/ Project 3/ Core D]
Nikolić D. CASMI 2016: A manual approach for dereplication of natural products using tandem mass spectrometry. Phytochem Lett. 2017; 21:292-296. [Core D]
Simmler C, Lankin DC, Nikolić D, van Breemen RB, Pauli GF. Isolation and structural characterization of dihydrobenzofuran congeners of licochalcone A. Fitoterapia. 2017; 121:6-15. [Project 1/ Core B/ Core D]
Nikolić D, Macias C, Lankin DC, van Breemen RB. Collision-induced dissociation of phenethylamides: role of ion-neutral complexes. Rapid Commun Mass Spectrom. 2017; 31:1385-1395. [Core D]
Keiler AM, Macejova D, Dietz BM, Bolton JL, Pauli GF, Chen SN, van Breemen RB, Nikolic D, Goerl F, Muders MH, Zierau O, Vollmer G. Evaluation of estrogenic potency of a standardized hops extract on mammary gland biology and on MNU-induced mammary tumor growth in rats. J Steroid Biochem Mol Biol. 2017. [Project 1/ Core B/ Project 2/ Core C/ Project 3/ Core D]
Keiler AM, Helle J, Bader MI, Ehrhardt T, Nestler K, Kretzschmar G, Bernhardt R, Vollmer G, Nikolić D, Bolton JL, Pauli GF, Chen SN, Dietz BM, van Breemen RB, Zierau O. A standardized Humulus lupulus (L.) ethanol extract partially prevents ovariectomy-induced bone loss in the rat without induction of adverse effects in the uterus. Phytomedicine. 2017; 34:50-58. [Project 1/ Core B/ Project 2/ Core C/ Project 3/ Core D]
Dunlap TL, Howell CE, Mukand N, Chen SN, Pauli GF, Dietz BM, Bolton JL. Red Clover Aryl Hydrocarbon Receptor (AhR) and Estrogen Receptor (ER) Agonists Enhance Genotoxic Estrogen Metabolism. Chem Res Toxicol. 2017. [Project 1/ Core B/ Project 2/ Core C]
Huang L, Nikolic D, van Breemen RB. Hepatic metabolism of licochalcone A, a potential chemopreventive chalcone from licorice (Glycyrrhiza inflata), determined using liquid chromatography-tandem mass spectrometry. Anal Bioanal Chem. Nov 2017. [Project 3/ Core D]Simmler C, Graham JG, Chen S, Pauli GF. Integrated analytical assets aid botanical authenticity and adulteration management. Fitoterapia. 2017 Nov;xxx:x-x. PMID: 29175549 [Project 1/ Core B] -
2016 (14)
AbouZid SF, Chen SN, McAlpine JB, Friesen JB, Pauli GF. Silybum marianum pericarp yields enhanced silymarin products. Fitoterapia. 2016; 112:136-143. [Project 1/ Core B]
AbouZid SF, Chen SN, Pauli GF. Silymarin content in Silybum marianum populations growing in Egypt. Ind Crops Prod. 2016; 83: 729-737. [Project 1/ Core B]
Bisson J, McAlpine J, Friesen JB, Chen SN, Graham J, Pauli GF. Can Invalid Bioactives Undermine Natural Product-Based Drug Discovery? J Med Chem. 2016; 59:1671-1690. [Project 1/ Core B]
Bolton JL. Menopausal Hormone Therapy, Age, and Chronic Diseases: Perspectives on Statistical Trends. Chem Res Toxicol. 2016; 29: 1583-1590. [Project 2/ Core C]
Dietz BM, Hajirahimkhan A, Dunlap T, Bolton JL. Botanicals and Their Bioactive Phytochemicals for Women’s Health. Pharmacol Rev 2016; 68: 1026-1073. [Project 2/ Core C]
Imai A, Lankin D, Nikolic D, Ahn S, van Breemen RB, Farnsworth N, Chen S-N, Pauli GF. Cycloartane triterpenes from the aerial parts of Actaea racemosa. J Nat Prod. 2016; 79:541-554. [Project 1/ Core B/ Core D]
Li G, Nikolic D, van Breemen RB. Identification and Chemical Standardization of Licorice Raw Materials and Dietary Supplements Using UHPLC-MS/MS. J Agric Food Chem. 2016 [Project 3/ Core D]
Liu Y, Garzon J, Friesen JB, Zhang Y, McAlpine JB Lankin DC, Chen SN, Pauli GF. Countercurrent assisted quantitative recovery of metabolites from plant-associated natural deep eutectic solvents. Fitoterapia. 2016; 112:30-37. [Project 1/ Core B]
Rush MD, Walker EM, Burton T, van Breemen RB. Magnetic Microbead Affinity Selection Screening (MagMASS) of Botanical Extracts for Inhibitors of 15-Lipoxygenase. J Nat Prod. 2016. [Project 3/ Core D]
Simmler C, Chen SN, Anderson J, Lankin DC, Phansalkar R, Krause E, Dietz B, Bolton JL, Nikolic D, van Breemen RB, Pauli GF. Botanical Integrity: Part 2 Traditional and Modern Analytical Approaches.HerbalGram. 2016; 109:60-64. [Project 1/ Project 2/ Project 3/ Core A/ Core B/ Core C/ Core D]
Simmler C, Kulakowski D, Lankin DC, McAlpine JB, Chen SN, Pauli GF. Holistic Analysis Enhances the Description of Metabolic Complexity in Dietary Natural Products. Adv Nutr. 2016; 7(1):179-89. [Project 1/ Core B]
Sprouse AA, van Breemen RB. Pharmacokinetic Interactions between Drugs and Botanical Dietary Supplements. Drug Metab Dispos. 2016; 44(2):162-71. [Project 3]
van Breemen RB, Wright B, Li Y, Nosal D, Burton T. Standardized grape powder for basic and clinical research. In Grapes and Health. Ed. By Pezzuto JM. Springer International Publishing, Basel, Switzerland, pp 17-26, 2016.
Wang S, Dunlap T, Howell C, Mbachu O, Rue E, Phansalkar R, Chen SN, Pauli G, Dietz B, Bolton J. Hop (Humulus lupulus L.) extract and 6-prenylnaringenin induce P450 1A1 catalyzed estrogen 2-hydroxylation. Chem Res Tox. 2016; Epub ahead of print. [Project 1/ Core B/ Project 2/ Core C]
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2015 (10)
Dunlap TL, Wang S, Simmler C, Chen SN, Pauli GF, Dietz BM, Bolton JL. Differential Effects of Glycyrrhiza Species on Genotoxic Estrogen Metabolism: Licochalcone A Downregulates P450 1B1, whereas Isoliquiritigenin Stimulates It. Chem Res Toxicol. 2015; 28:1584-94. [Project 1/ Project 2/ Core B/ Core C]
Friesen JB, McAlpine JB, Chen SN, Pauli GF. Countercurrent Separation of Natural Products: An Update. Review article J Nat Prod. 2015; 78:1765-96. [Project 1/ Core B]
Hajirahimkhan A, Simmler C, Dong H, Lantvit DD, Li G, Chen SN, Nikolic D, Pauli GF, van Breemen RB, Dietz BM, Bolton JL. Induction of NAD(P)H:Quinone Oxidoreductase 1 (NQO1) by Glycyrrhiza Species Used for Women’s Health: Differential Effects of the Michael Acceptors Isoliquiritigenin and Licochalcone A. Chem Res Toxicol. 2015; 28:2130-2141. [Project 1/ Project 2/ Project 3/ Core B/ Core C/ Core D]
Huang K, Huang L, van Breemen RB. Detection of reactive metabolites using isotope-labeled glutathione trapping and simultaneous neutral loss and precursor ion scanning with ultra-high-pressure liquid chromatography triple quadruple mass spectrometry. Anal Chem. 2015; 87:3646-3654. [Project 3/ Core D]
Li G, Huang K, Nikolic D, van Breemen RB. High-Throughput Cytochrome P450 Cocktail Inhibition Assay for Assessing Drug-Drug and Drug-Botanical Interactions. Drug Metab Dispos. 2015; 43:1670-8. [Project 3/ Core D]
Liu Y, Friesen JB, McAlpine JB, Pauli GF. Solvent System Selection Strategies in Countercurrent Separation. Planta Med. 2015; 81:1582-91. [Project 1/ Core B]
Nikolić D, Lankin DC, Cisowska T, Chen S, Pauli GF, van Breemen RB. Nitrogen-containing constituents of black cohosh: Chemistry, structure elucidation, and biological activities. The Formation, Structure and Activity of Phytochemicals. Recent Advances in Phytochemistry 45. Ed. By Jetter R. Springer International Publishing, Switzerland 2015; 31-75. [Project 1/ Project 3/ Core B/ Core D]
Simmler C, Chen S-N, Anderson J, Lankin DC, Phansalkar R, Krause E, Dietz B, Bolton JL, Nikolic D, van Breemen RB, Pauli GF. Botanical integrity (I) scientific concepts of botanical integrity and the role of DNA barcoding. HerbalGram. 2015; 12(4). [Project 1/ Project 2/ Project 3/ Core A/ Core B/ Core C/ Core D]
Simmler C, Anderson JR, Gauthier L, Lankin DC, McAlpine JB, Chen SN, Pauli GF. Metabolite Profiling and Classification of DNA-Authenticated Licorice Botanicals. J Nat Prod. 2015; 78: 2007-22. [Project 1/ Core B / Core D]
van Breemen RB. Development of Safe and Effective Botanical Dietary Supplements. J Med Chem. 2015; 58(12):8360-72 [Project 3/ Core D]
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2014 (14)
Bolton JL. Quinone methide bioactivation pathway: contribution to toxicity and/or cytoprotection? Curr Org Chem. 2014; 18:61-69. [Project 2/ Core C].
Krause E, Yuan Y, Hajirahimkhan A, Dong H, Dietz BM, Nikolic D, Pauli GF, Bolton JL, van Breemen RB. Biological and chemical standardization of a hop (Humulus lupulus) botanical dietary supplement. Biomed Chromatogr. 2014; 28:729-734. [Project 1 /Project2 /Project3 /Core A/ Core B/ Core C/ Core D]
Nikolić D, Li J, van Breemen RB. Metabolism of Nω-methylserotonin, a serotonergic constituent of black cohosh (Cimicifuga racemosa, L. (Nutt.)), by human liver microsomes. Biomed Chromatogr. 2014; 28: 1647-1651. [Project 3/ Core D]
Pauli GF, Chen SN, Lankin DC, Bisson J, Case RJ, Chadwick LR, Godecke T, Inui T, Krunic A, Jaki BU, McAlpine JB, Mo S, Napolitano JG, Orjala J, Lehtivarjo J, Korhonen SP, Niemitz M. Essential parameters for structural analysis and dereplication by (1)H NMR spectroscopy. J Nat Prod. 2014; 77:1473-1487. [Project 1/ Core B/ Core D]
Pauli GF, Chen SN, Simmler C, Lankin DC, Godecke T, Jaki BU, Friesen JB, McAlpine JB, Napolitano JG. Importance of purity evaluation and the potential of quantitative ¹H NMR as a purity assay. Review article J Med Chem. 2014; 57:9220-9231. [Project 1/ Core B/ Core D]
Qiu F, Chen S-N, McAlpine JB, Krause EC, Pauli GF. Progress in pharmacognostic studies of Actaea racemosa. In Progress in the Chemistry of Organic Natural Products. Vol 99, 2014. [Project 1/ Core A/ Core B]
Qiu F, McAlpine JB, Lankin DC, Burton I, Karakach T, Chen S-N, Pauli GF. 2D NMR barcoding and differential analysis of complex mixtures for chemical identification: the Actaea triterpenes. Anal Chem. 2014; 86:3964-3972. [Project 1/ Core B/ Core D]
Ramos Alvarenga RF, Friesen JB, Nikolic D, Simmler C, Napolitano JG, van Breemen R, Lankin DC, McAlpine JB, Pauli GF, Chen SN. K-targeted metabolomic analysis extends chemical subtraction to DESIGNER extracts: selective depletion of extracts of hops (Humulus lupulus). J Nat Prod. 2014; 77:2595-2604. [Project 1/ Project 3/ Core B/ Core D]
Simmler C, Jones T, Anderson JR, Nikolic DC, van Breemen RB, Soejarto DD, Chen SN, Pauli GF. Species-specific Standardisation of Licorice by Metabolomic Profiling of Flavanones and Chalcones. Phytochem Anal. 2014; 25:378-388. [Project 1/ Project 3/ Core B/ Core D]
Simmler C, Napolitano JG, McAlpine JB, Chen SN, Pauli GF. Universal quantitative NMR analysis of complex natural samples. Curr Opin Biotechnol. 2014; 25c:51-9. [Project 1/ Core B]
Simmler C, Nikolić D, Lankin DC, Yu Y, Friesen JB, van Breemen RB, Lecomte A, Le Quémener C, Audo G, Pauli GF. Orthogonal Analysis Underscores the Relevance of Primary and Secondary Metabolites in Licorice. J Nat Prod. 2014; 77(8):1806-16 [Project 1/Core B/Core D]
Toh MF, Mendonca E, Eddie SL, Endsley MP, Lantvit DD, Petukhov PA, Burdette JE. Kaempferol Exhibits Progestogenic Effects in Ovariectomized Rats. J Steroids Horm Sci. 2014; 5:136. [Core A/ Pilot Project]
van Breemen RB, Yuan Y, Banuvar S, Shulman LP, Xi Qiu X, Ramos Alvarenga RF, Chen S-N, Dietz BM, Bolton JL, Pauli GF, Krause E, Viana M, Nikolic D. Pharmacokinetics of prenylated hop phenols in women following oral administration of a standardized extract of hops. Mol Nutr Food Res. 2014; 58:1962-1969. [Project 1/ Project 2/ Project 3/ Core A/ Core B/ Core C/ Core D]
Yuan Y, Qiu X, Nikolic D, Chen SN, Huang K, Li G, Pauli GF, van Breemen RB. Inhibition of human cytochrome P450 enzymes by hops (Humulus lupulus) and hop prenylphenols. Eur J Pharm Sci. 2014; 53:55-61. [Project 1/ Project 3/ Core B/ Core D]
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2013 (15)
Dietz BM, Bolton JL. Anti-inflammatory botanical dietary supplements for women’s health: Role in breast cancer prevention? Book section In: Inflammation and Cancer: Mechanisms and Dietary Approaches for Cancer Prevention (Kong AN, Ed.) CRC Press – Taylor and Francis Group, pp 529-548, 2013. [Project 2/ Core C]
Dietz BM, Hagos GK, Eskra JN, Wijewickrama GT, Anderson JR, Nikolic D, Guo J, Wright B, Chen SN, Pauli GF, van Breemen RB, Bolton JL. Differential regulation of detoxification enzymes in hepatic and mammary tissue by hops (Humulus lupulus) in vitro and in vivo. Mol Nutr Food Res. 2013; 57:1055-1066. [Project 1/ Project 2/ Project 3/ Core B/ Core C/ Core D]
Dong SH, Cai G, Napolitano JG, Nikolic D, Lankin DC, McAlpine JB, van Breemen RB, Soejarto DD, Pauli GF, Chen SN. Lipidated steroid saponins from Dioscorea villosa (wild yam). Fitoterapia. 2013; 91:113-124. [Project 1/ Project 3/ Core B/ Core D]
Drogos LL, Rubin LH, Geller SE, Banuvar S, Shulman LP, Maki PM. Objective cognitive performance is related to subjective memory complaints in midlife women with moderate to severe vasomotor symptoms. Menopause. 2013; 20:1236-1242. [Core A]
Hajirahimkhan A, Dietz BM, Bolton JL. Botanical modulation of menopausal symptoms: mechanisms of action? Planta Med. 2013; 79:538-553. [Project 2/ Core C]
Hajirahimkhan A, Simmler C, Yuan Y, Anderson JR, Chen SN, Nikolic D, Dietz BM, Pauli GF, van Breemen RB, Bolton JL. Evaluation of estrogenic activity of licorice species in comparison with Hops used in botanicals for menopausal symptoms. PLoS One. 2013; 8(7):e67947. [Project 1/ Project 2/ Project 3/ Core B/ Core C/ Core D]
Mo S, Dong L, Hurst WJ, van Breemen RB. Quantitative analysis of phytosterols in edible oils using APCI liquid chromatography-tandem mass spectrometry. Lipids. 2013; 48(9):949-956. [Project 3/ Core D]
Nikolic D, van Breemen RB. Analytical methods for quantitation of prenylated flavonoids from hops. Curr Anal Chem. 2013; 9:71-85. [Project 3/ Core D]
Overk CR, Bolton JL. Screening and mechanism-based evaluation of estrogenic botanical extracts. In Advances in Combinatorial Chemistry and High Throughput Screening, Vol 1, Ed. Rathnam Chaguturu, Bentham Science. 2013; pp. 159-186. [Project 2/ Core C]
Simmler C, Fronczek FR, Pauli GF, Santarsiero BD. Absolute configuration of naturally occurring glabridin. Acta Crystallogr C. 2013; 69:1212-1216. [Project 1/ Core B]
Simmler C, Hajirahimkhan A, Lankin DC, Bolton JL, Jones T, Soejarto DD, Chen SN, Pauli GF. Dynamic residual complexity of the isoliquiritigenin-liquiritigenin interconversion during bioassay. J Agric Food Chem. 2013; 61:2146-2157. [Project 1/ Project 2/ Core B/ Core C/ Core D]
Simmler C, Pauli GF, Chen SN. Phytochemistry and biological properties of glabridin. Fitoterapia. 2013; 90:160-184. [Project 1/ Core B]
Yu R, Zhao G, Christman JW, Xiao L, van Breemen RB. Method development and validation for ultra-high pressure liquid chromatography/tandem mass spectrometry determination of multiple prostanoids in biological samples. J AOAC Int. 2013; 96:67-76. [Project 3/ Core D]
Yuan Y, Yu LF, Qiu X, Kozikowski AP, van Breemen RB. Pharmacokinetics and brain penetration of LF-3-88, (2-[5-[5-(2(S)-azetidinylmethoxyl)-3-pyridyl]-3-isoxazolyl]ethanol), a selective α4β2-nAChR partial agonist and promising antidepressant. J Chromatogr B Analyt Technol Biomed Life Sci. 2013; 912:38-42. [Project 3/ Core D]
Zhao G, Yu R, Deng J, Zhao Q, Li Y, Joo M, van Breemen RB, Christman JW, Xiao L. Pivotal role of reactive oxygen species in differential regulation of lipopolysaccharide-induced prostaglandins production in macrophages. Mol Pharmacol. 2013; 83:167-178. [Project 3/ Core D]
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2012 (13)
Dong SH, Nikolic D, Simmler C, Qiu F, van Breemen RB, Soejarto DD, Pauli GF, Chen SN. Diarylheptanoids from Dioscorea villosa (Wild Yam). J Nat Prod. 2012; 75:2168-2177. [Project 1/ Project 3/ Core B/ Core D]
Godecke T, Yao P, Napolitano JG, Nikolic D, Dietz BM, Bolton JL, van Breemen RB, Farnsworth NR, Chen SN, Lankin DC, Pauli GF. Integrated standardization concept for Angelica botanicals using quantitative NMR. Fitoterapia. 2012; 83:18-32. [Project 1/ Project 2/ Project 3/ Core B/ Core C/ Core D]
Hemachandra LP, Madhubhani P, Chandrasena R, Esala P, Chen S-N, Main M, Lankin DC, Scism RA, Dietz BM, Pauli GF, Thatcher GR, Bolton JL. Hops (Humulus lupulus) inhibits oxidative estrogen metabolism and estrogen-induced malignant transformation in human mammary epithelial cells (MCF-10A). Cancer Prev Res. 2012; 5:73-81. [Cited in “Looking Forward to 2013 – Saluting the Exceptional Year in 2012”, Scott M. Lippman, Cancer Prev Res. (2013) 6:1-3]. [Project 1/ Project 2/ Project 3/ Core B/ Core C/ Core D]
Hu C, Nikolic D, Eggler AL, Mesecar AD, van Breemen RB. Screening for natural chemoprevention agents that modify human Keap1. Anal Biochem. 2012; 421:108-114. [Project 3/ Core D]
Nikolic D, Godecke T, Chen SN, White J, Lankin DC, Pauli GF, van Breemen RB. Mass spectrometric dereplication of nitrogen-containing constituents of black cohosh (Cimicifuga racemosa L.). Fitoterapia. 2012; 83:441-460. [Project 1/ Project 3/ Core B/ Core D]
Pauli GF, Godecke T, Jaki BU, Lankin DC. Quantitative 1H NMR. Development and potential of an analytical method: an update. J Nat Prod. 2012; 75:834-851. [Project 1/ Core B/ Core D]
Qiu F, Imai A, McAlpine JB, Lankin DC, Burton I, Karakach T, Farnsworth NR, Chen SN, Pauli GF. Dereplication, residual complexity, and rational naming: the case of the Actaea triterpenes. J Nat Prod. 2012; 75:432-443. [Project 1/ Core B/ Core D]
Snelten CS, Dietz B, Bolton JL. Modulation of estrogen chemical carcinogenesis by botanical supplements used for postmenopausal women’s health. Drug Discov Today Dis Mech. 2012; 9:47-51 [Project 2/ Core C]
Toh MF, Sohn J, Chen SN, Yao P, Bolton JL, Burdette JE. Biological characterization of non-steroidal progestins from botanicals used for women’s health. Steroids 2012; 77:765-773. [Project 2/ Core B/ Core C]
van Breemen RB, Dong L, Pajkovic ND. Atmospheric pressure chemical ionization tandem mass spectrometry of carotenoids. Int J Mass Spectrom. 2012; 312:163-172. [Project 3/ Core D]
Viana M. Chapter 11, In Mathematical Optics: Classical, Quantum, and Computational Methods(Lakshminarayanan, et al. Eds.) CRC Press, 2012. [Core A]
Viana, AG. Marlos, Lakshminarayanan, Vasudevan. Dihedral Fourier Analysis: Data-analytic Aspects and Applications. Nov. 2012. Springer [Core A]
Yuan Y, Qiu X, Nikolic D, Dahl JH, van Breemen RB. Method development and validation for ultra-high-pressure LC/MS/MS determination of hop prenylflavonoids in human serum. J AOAC Int. 2012; 95:1744-1749. [Project 3/ Core D]
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2011 (11)
Bolton JL. Mechanisms of estrogen carcinogenesis: Modulation by botanical natural products. In Chemical Carcinogenesis (Penning TM., Ed.), Springer, New York, NY, pp 75-93, 2011. [Project 2/ Core C].
Cao H, Yu R, Tao Y, Nikolic D, van Breemen RB. Measurement of cyclooxygenase inhibition using liquid chromatography-tandem mass spectrometry. J Pharm Biomed Anal. 2011; 54:230-235. [Project 3/ Core D]
Chen SN, Friesen JB, Webster D, Nikolic D, van Breemen RB, Wang ZJ, Fong HH, Farnsworth NR, Pauli GF. Phytoconstituents from Vitex agnus-castus fruits. Fitoterapia. 2011; 82:528-33. [Project 1/ Project 3/ Core B/ Core D]
Choi Y, Jermihov K, Nam SJ, Sturdy M, Maloney K, Qiu X, Chadwick LR, Main M, Chen SN, Mesecar AD, Farnsworth NR, Pauli GF, Fenical W, Pezzuto JM, van Breemen RB. Screening natural products for inhibitors of quinone reductase-2 using ultrafiltration LC-MS. Anal Chem. 2011; 83:1048-52. [Project 1/ Project 3/ Core B/ Core D]
Dietz BM, Bolton JL. Biological reactive intermediates (BRIs) formed from botanical dietary supplements. Chem Biol Interact. 2011; 192:72-80. [Project 2/ Core C]
Hu C, Eggler AL, Mesecar AD, van Breemen RB. Modification of keap1 cysteine residues by sulforaphane. Chem Res Toxicol. 2011; 24:515-521. [Project 3/ Core D]
Li J, Godecke T, Chen SN, Imai A, Lankin DC, Farnsworth NR, Pauli GF, van Breemen RB, Nikolic D. In vitro metabolic interactions between black cohosh (Cimicifuga racemosa) and tamoxifen via inhibition of cytochromes P450 2D6 and 3A4. Xenobiotica. 2011; 41:1021-1030. [Project 1/ Project 3/ Core B/ Core D]
Shulman LP, Banuvar S, Fong HH, Farnsworth NR. Discussion of a well-designed clinical trial which did not demonstrate effectiveness: UIC Center for Botanical Dietary Supplements Research study of black cohosh and red clover. Fitoterapia. 2011; 82:88-91. [Project 1/ Project 4]
van Breemen RB, Tao Y, Li W. Cyclooxygenase-2 inhibitors in ginger (Zingiber officinale). Fitoterapia. 2011; 82:38-43. [Project 3/ Core D]
Webster DE, He Y, Chen SN, Pauli GF, Farnsworth NR, Wang ZJ. Opioidergic mechanisms underlying the actions of Vitex agnus-castus L. Biochem Pharmacol. 2011; 81:170-177. [Project 1/ Core B]
Yu R, Xiao L, Zhao G, Christman JW, van Breemen RB. Competitive enzymatic interactions determine the relative amounts of prostaglandins E2 and D2. J Pharmacol Exp Ther. 2011; 339:716-725. [Project 3/ Core D]
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2010 (5)
Bolca S, Li J, Nikolic D, Roche N, Blondeel P, Possemiers S, De Keukeleire D, Bracke M, Heyerick A, van Breemen RB, Depypere H. Disposition of hop prenylflavonoids in human breast tissue. Mol Nutr Food Res. 2010; 54 Suppl 2: S284-S294. [Project 3 /Core D]
Cao H, Yu R, Choi Y, Ma ZZ, Zhang H, Xiang W, Lee DY, Berman BM, Moudgil KD, Fong HH, van Breemen RB. Discovery of cyclooxygenase inhibitors from medicinal plants used to treat inflammation. Pharmacol Res. 2010; 61:519-524. [Project 3 /Core D]
Fabricant DS, Krause EC, Farnsworth NR. Black Cohosh. In Encyclopedia of Dietary Supplements (Coates PM, Ed), Informa Healthcare, New York, NY, pp 60-74, 2010. [Project 1/ Core A/]
Krause EC, Booth NL, Piersen CE, Farnsworth NR. Red Clover. In Encyclopedia of Dietary Supplements (Coates PM, Ed) Informa Healthcare, New York, NY, pp 665-679, 2010. [Project 1/ Core A]
van Breemen RB, Liang W, Banuvar S, Shulman LP, Pang Y, Tao Y, Nikolic D, Krock KM, Fabricant DS, Chen SN, Hedayat S, Bolton JL, Pauli GF, Piersen CE, Krause EC, Geller SE, Farnsworth NR. Pharmacokinetics of 23-epi-26-deoxyactein in women after oral administration of a standardized extract of black cohosh. Clin Pharmacol Ther. 2010; 87:219-225. [Project 1 /Project2 /Project3 /Core A/ Core B/ Core C/ Core D]
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2009 (10)
Geller SE, Shulman LP, van Breemen RB, Banuvar S, Zhou Y, Epstein G, Hedayat S, Nikolic D, Krause EC, Piersen CE, Bolton JL, Pauli GF, Farnsworth NR. Safety and efficacy of black cohosh and red clover for the management of vasomotor symptoms: a randomized controlled trial. Menopause. 2009; 16:1156-1166. PMC2783540 [NIHMS: 135600]
Goedecke T, Lankin DC, Nikolic D, Chen S-N, van Breemen RB, Farnsworth NR, Pauli GF. Guanidine alkaloids and Pictet-Spengler adducts from black cohosh (Cimicifuga racemosa). J Nat Prod. 2009; 72:433-437. PMC2765500 [All Center]
Godecke T, Nikolic D, Lankin DC, Chen SN, Powell SL, Dietz B, Bolton JL, van Breemen RB, Farnsworth NR, Pauli GF. Phytochemistry of cimicifugic acids and associated bases in black cohosh root extracts. Phytochem Anal. 2009; 20: 120-131. PMC2715282 [All Center]
Maki PM, Rubin LH, Fornelli D, Drogos L, Banuvar S, Shulman LP, Geller SE. Effects of botanicals and combined hormone therapy on cognition in postmenopausal women. Menopause. 2009, [Project 4, Core A- Pilot Project]
van Breemen RB, Liang W, Banuvar S, Shulman L, Pang Y, Tao Y, Nikolic D, Krock KM, Fabricant DS, Chen S-N, Hedayat S, Bolton JL, Pauli GF, Piersen CE, Krause EC, Geller SE, Farnsworth NR. Pharmacokinetics of 23-epi-26-deoxyactein in women after oral administration of a standardized extract of black cohosh. Clin Pharmacol Ther. 2010;87:219-225. [All Center]
Calderon AI, Wright BJ, Hurst WJ, van Breemen RB. Screening antioxidants using LC-MS: case study with cocoa. J Agric Food Chem. 2009;57:5693-5699. PMC2736061 [Project 3 /Core D]
Chen SN, Lankin DC, Chadwick LR, Jaki BU, Pauli GF. Dynamic residual complexity of natural products by qHNMR: solution stability of desmethylxanthohumol. Planta Med. 2009;75:757-762. PMC2760692 [Project 1 /Core B /CoreD]
Eggler AL, Small E, Hannink M, Mesecar AD. Cul3-mediated Nrf2 ubiquitination and antioxidant response element (ARE) activation are dependent on the partial molar volume at position 151 of Keap1. Biochem J. 2009;422:171-180. PMC3865926 [All Center]
McClatchey WC, Mahady GB, Bennett BC, Shiels L, Savo V. Ethnobotany as a pharmacological research tool and recent developments in CNS-active natural products from ethnobotanical sources. Pharmacol Ther. 2009;123:239-254. PMC2700180 [All Center]
Tao Y, Li W, Liang W, Van Breemen RB. Identification and quantification of gingerols and related compounds in ginger dietary supplements using high-performance liquid chromatography-tandem mass spectrometry. J Agric Food Chem. 2009;57:10014-21. PMC2783668 [Project 3 /Core D]
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2008 (17)
Barnes S, Birt DF, Cassileth BR, Cefealu WT, Chilton FH, Farnsworth NR, Raskin I, van Breemen RB, Weaver CM. Technologies and experimental approaches at the National Institutes of Health Botanical Research Centers. Am J Clin Nutrit. 2008;87:476S-80S. PMC2715852 [Core A]
Chen SN, Turner A, Jaki BU, Nikolic D, van Breemen RB, Friesen JB, Pauli GF. An experimental implementation of chemical subtraction. J Pharm Biomed Anal. 2008;46:692-698. PMC2292113 [Project 1/ Project 3/ Core C]
Choi Y, van Breemen RB. Development of a screening assay for ligands to the estrogen receptor based on magnetic microparticles and LC-MS. Comb Chem High Throughput Screen. 2008;11:1-6. PMC2736128 [Project 3]
Deng S, Wang Y, Inui T, Chen SN, Farnsworth NR, Cho S, Franzblau SG, Pauli GF. Anti-TB polyynes from the roots of Angelica sinensis. Phytother Res. 2008;22:878-882. PMC2504689 [Project 1]
Dietz BM, Liu D, Hagos GK, Yao P, Schinkovitz A, Pro SM, Deng S, Farnsworth NR, Pauli GF, van Breemen RB, Bolton JL. Angelica sinensis and its alkylphthalides induce the detoxification enzyme NAD(P)H: quinone oxidoreductase 1 by alkylating Keap1. Chem Res Toxicol. 2008;21:1939-1948. PMC2615640 [All Center]
Dong Y, Hedayat AS, Sinha BK. Surveillance strategies for detecting changepoint in incidence rate based on exponentially weighted moving average methods. J Am Statist Assoc. 2008;103:843.
Fang X, Hedayat AS. Locally D-optimal designs based on a class of composed models resulted from blending Emax and one-compartment models. Ann Stat. 2008;36:428.
Farnsworth NR, Krause EC, Bolton JL, Pauli GF, van Breemen RB, Graham JG. The University of Illinois at Chicago/National Institutes of Health Center for Botanical Dietary Supplements Research for Women’s Health: from plant to clinical use. Am J Clin Nutr. 2008;87:504S-508S. PMC3645894 [Project 1/ Project 2/ Project 3/ Core A]
Hedayat AS, Su G, Elane Streets W. Statistical scoring procedures applicable to laboratory performance evaluation. J Statist Plan Infer. 2008;138:3336. [Core A]
Hedayat AS, Yan Z. Crossover designs based on type I orthogonal arrays for a self and simple mixed carryover effects model with correlated errors. J Statist Plan Infer. 2008;138:2201. [Core A]
Maki PM, Drogos LL, Rubin LH, Banuvar S, Shulman LP, Geller SE. Objective hot flashes are negatively related to verbal memory performance in midlife women. Menopause 2008; 15: 848-856 [Project4/ Core A- Pilot Project]
Overk CR, Guo J, Chadwick LR, Lanvit DD, Minassi A, Appendino G, Chen SN, Lankin DC, Farnsworth NR, Pauli GF, van Breemen RB, Bolton JL. In vivo estrogenic comparisons of Trifolium pratense (red clover) Humulus lupulus (hops), and the pure compounds isoxanthohumol and 8-prenylnaringenin. Chem Biol Interact. 2008;176:30-39. PMC2574795 [All Center]
Overk CR, Yao P, Chen S, Deng S, Imai A, Main M, Schinkivitz A, Farnsworth NR, Pauli GF, Bolton JL. High-content screening and mechanism-based evaluation of estrogenic botanical extracts. Comb Chem High Throughput Screen. 2008;11:283-293. PMC3219440 [Project 1/ Project 2]
Pauli GF, Pro SM, Friesen JB. Countercurrent separation of natural products. J Nat Prod. 2008;71:1489-508. [Project 1]
Powell SL, Goedecke T, Nikolic D, Chen SN, Ahn S, Dietz B, Farnsworth NR, van Breemen RB, Lankin DC, Pauli GF, Bolton JL. In vitro serotonergic activity of black cohosh and identification of N(omega)-methylserotonin as a potential active constituent. J Agric Food Chem. 2008;56:11718-26. PMC3684073 [Project 1/ Project 2/ Project 3/ Core C]
Schinkovitz A, Pro SM, Main M, Chen SN, Jaki BU, Lankin DC, Pauli GF. Dynamic nature of the ligustilide complex. J Nat Prod. 2008;71:1604-11. PMC2614662 [Project 1]
van Breemen RB, Fong HH, Farnsworth NR. Ensuring the safety of botanical dietary supplements. Am J Clin Nutr. 2008;87:509S-13S. [Core A]
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2007 (13)
Chen SN, Lankin DC, Nikolic D, Fabricant DS, Lu ZZ, Ramirez B, van Breemen RB, Fong HH, Farnsworth NR, Pauli GF. Chlorination diversifies Cimicifuga racemosa triterpene glycosides. J Nat Prod. 2007;70:1016-23. PMC2596075 [Core B/ Project 1]
Dietz B, Bolton JL. Botanical dietary supplements gone bad. Chem Res Toxicol. 2007;20:586-90. [Project 2]
Eggler AL, Luo Y, van Breemen RB, Mesecar AD. Identification of the highly reactive cysteine 151 in the chemopreventive agent-sensor Keap1 protein is method-dependent. Chem Res Toxicol. 2007;20:1878-1884. [Project 3/ Core C]
Geller SE, Studee L. Botanical and dietary supplements for mood and anxiety in menopausal women. Menopause. 2007;14:541-9 [Project 4]
Hedayat AS, Lin L, Wu W. A unified approach for assessing agreement for continuous and categorical data. J Biopharm. Stat. 2007;17:629-652. [Core A/ Project 4]
Hedayat AS, Pesotan H. Tools for constructing optimal two-level factorial designs for a linear model containing main effects and one two-factor interaction. J Statist Plan Infer. 2007;137:1452. [Core A/ Project 4]
Li W, Xu X, Zhang H, Ma C, Fong H, van Breemen RB, Fitzloff J. Secondary metabolites from Andrographis paniculata. Chem Pharm Bull (Tokyo). 2007;55:455-458 [Core A/ Core B/ Project 3]
Luo Y, Eggler AL, Liu D, Liu G, Mesecar AD, van Breemen RB. Sites of alkylation of human Keap1 by natural chemoprevention agents. J Am Soc Mass Spectrom. 2007;18:2226-32. PMC214474 [Project 3]
Pang Y, Nikolic D, Zhu D, Chadwick LR, Pauli GF, Farnsworth NR, van Breemen RB. Binding of the hop (Humulus lupulus L.) chalcone xanthohumol to cytosolic proteins in Caco-2 intestinal epithelial cells. Mol Nutr Food Res. 2007;51:872-879. [Core A/ Core B/ Project 1/ Project 3]
Pauli GF, Jaki BU, Lankin DC. A routine experimental protocol for qHNMR illustrated with Taxol. J Nat Prod. 2007;70:589-595. [Project 1]
Qiu SX, Dan C, Ding LS, Peng S, Chen SN, Farnsworth NR, Nolta J, Gross ML, Zhou P. A triterpene glycoside from black cohosh that inhibits osteoclastogenesis by modulating RANKL and TNFalpha signaling pathways. Chem Biol. 2007;14:860-869. [Project 1]
Turner A, Chen SN, Nikolic D, van Breemen R, Farnsworth NR, Pauli GF. Coumaroyl iridoids and a depside from cranberry (Vaccinium macrocarpon). J Nat Prod. 2007;70:253-258. PMC1847405 [Core B/ Project 1]
van Breemen RB, Fong HH, Farnsworth NR. The role of quality assurance and standardization in the safety of botanical dietary supplements. Chem Res Toxicol. 2007;20:577-582. PMC2570109 [Core A/ Core B/ Project 1/ Project 3]
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2006 (17)
Booth NL, Overk CR, Yao P, Burdette JE, Nikolic D, Chen SN, Bolton JL, van Breemen RB, Pauli GF, Farnsworth NR. The chemical and biologic profile of a red clover (Trifolium pratense L.) phase II clinical extract. J Alt. Compl Med. 2006;12:133-139. PMC1780253 [Project 1/ Core B]
Booth NL, Overk CR, Yao P, yao P, Totura S, Deng Y, Hedayat AS, Bolton JL, Pauli GF, Farnsworth NR. Seasonal variation of red clover (Trifolium pratense L., Fabaceae) isoflavones and estrogenic activity. J Agric Food Chem. 2006;54:1277-1282. PMC1903374 [Project 1]
Booth NL, Piersen CE, Banuvar S, Geller SE, Shulman LP, Farnsworth NR. Clinical studies of red clover (Trifolium pratense) dietary supplements in menopause: a literature review. Menopause. 2006;13:251-264 [Project 1/ Project 4]
Chadwick LR, Pauli GF, Farnsworth NR. The pharmacognosy of Humulus lupulus L. (hops) with an emphasis on estrogenic properties. Phytomedicine. 2006;13:119-131. PMC1852439 [Project 1]
Deng S, Chen SN, Lu J. GABAergic phthalide dimers from Angelica sinensis (Oliv.) Diels. Phytochem Anal. 2006;17:398-405. [Project 1/ Core B].
Deng S, Chen SN, Yao P, Nikolic D, van Breemen RB, Bolton JL, Fong HH, Farnsworth NR, Pauli GF. Serotonergic activity-guided phytochemical investigation of the roots of Angelica sinensis. J Nat Prod. 2006;69:536-541. PMC1866289 [Project 1/ Core B]
Gafner S, Dietz BM, McPhail KL, Scott IM, Glinski JA, Russell FE, McCollum MM, Budzinski JW, Foster BC, Bergeron C, Rhyu MR, Bolton JL. Alkaloids from Eschscholzia californica and their capacity to inhibit binding of [3H]8-hydroxy-2-(di-N-propylamino)tetralin to 5-HT1A receptors in vitro. J Nat Prod. 2006;69:432-435. [Project 2]
Geller SE, Studee L. Contemporary alternatives to plant estrogens for menopause. Maturitas. 2006;55 Suppl 1:S3-13. PMC1780040 [Project 4]
Geller SE, Studee L. Soy and red clover for mid-life and aging. Climacteric. 2006;9:245-263. PMC1780039 [Project 4]
Guo J, Nikolic D, Chadwick LR, Pauli GF, van Breemen RB. Identification of human hepatic cytochrome P450 enzymes involved in the metabolism of 8-prenylnaringenin and isoxanthohumol from hops (Humulus lupulus L.). Drug Metab Dispos. 2006;34:1152-1159. [Project 3]
He K, Pauli GF, Zheng B, Wang H, Bai N, Peng T, Roller M, Zheng Q. Cimicifuga species identification by high performance liquid chromatography-photodiode array/mass spectrometric/evaporative light scattering detection for quality control of black cohosh products. J Chromatogr A. 2006;1112:241-254. PMC1847404 [Project 1]
Hedayat AS, Yan X, Lin L. Optimal designs in stability studies. J Biopharm Stat. 2006;16:35-59. [Core A]
Hedayat AS, Yang M. Efficient crossover designs for comparing test treatments with a control treatment. Discrete Math. 2006;306:3112-3124. [Core A]
Hedayat AS, Yang M. Optimal and efficient crossover designs when subject effects are random. J Am Statist Assoc. 2006; 101: 1031-1038. [Core A]
Nikolic D, Li Y, Chadwick LR, van Breemen RB. In vitro studies of intestinal permeability and hepatic and intestinal metabolism of 8-prenylnaringenin, a potent phytoestrogen from hops (Humulus lupulus L.). Pharm Res. 2006;23:864-872. PMC1764547 [Project 1/ Project 3/ Core B]
Rhyu MR, Lu J, Webster DE, Fabricant DS, Farnsworth NR, Wang ZJ. Black cohosh (Actaea racemosa, Cimicifuga racemosa) behaves as a mixed competitive ligand and partial agonist at the human mu opiate receptor. J Agric Food Chem. 2006;54:9852-9857. PMC2547488 [Project 1]
Webster DE, Lu J, Chen SN, Farnsworth NR, Wang ZJ. Activation of the mu-opiate receptor by Vitex agnus-castus methanol extracts: implication for its use in PMS. J Ethnopharmacol. 2006;106:216-221. [Project 1]
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2005 (20)
Chadwick LR, Fong HHS, Farnsworth NR, Pauli GF. CCC sample cutting for isolation of prenylated phenolics from hops. J. Liq. Chromatogr. Rel. Technol. 2005;28:1959-1969.
Chen SN, Fabricant DS, Pauli GF, Fong HH, Farnsworth NR. Synthesis of cimiracemate B, a phenylpropanoid found in Cimicifuga racemosa. Nat Prod Res. 2005;19:287-290.
Cheng X, van Breemen RB. Mass spectrometry-based screening for inhibitors of beta-amyloid protein aggregation. Anal Chem. 2005;77:7012-7015. PMC1780175 [Core B/ Project 3]
Conway WD, Chadwick LR, Fong HHS, Farnsworth NR, Pauli GF. Extra-column dead volume in countercurrent chromotography. J Liq Chromatogr Rel Technol. 2005;28:1799-1818. [Project 1]
Dietz BM, Kang YH, Liu G, Eggler AL, Yao P, Chadwick LR, Pauli GF, Farnsworth NR, Mesecar AD, van Breemen RB, Bolton JL. Xanthohumol isolated from Humulus lupulus Inhibits menadione-induced DNA damage through induction of quinone reductase. Chem Res Toxicol. 2005;18:1296-1305. [Project 1/ Project 2/ Project 3]
Dietz BM, Mahady GB, Pauli GF, Farnsworth NR. Valerian extract and valerenic acid are partial agonists of the 5-HT5a receptor in vitro. Mol. Brain Res. 2005;138:191-197. [Project 1/ Project 2/ Project 3]
Eggler AL, Liu G, Pezzuto JM, van Breemen RB, Mesecar AD. Modifying specific cysteines of the electrophile-sensing human Keap1 protein is insufficient to disrupt binding to the Nrf2 domain Neh2. Proc Natl Acad Sci U S A. 2005, 102:10070-10075. [Core C/ Project 3]
Fabricant DS, Nikolic D, Lankin DC, Chen SN, Jaki BU, Krunic A, van Breemen RB, Fong HH, Farnsworth NR, Pauli GF. Cimipronidine, a cyclic guanidine alkaloid from Cimicifuga racemosa. J Nat Prod. 2005;68:1266-1270. [Core A/ Core B/ Project 1/ Project 3]
Geller SE, Studee L. Botanical and dietary supplements for menopausal symptoms: what works, what does not. J Womens Health (Larchmt). 2005;14:634-649. PMC1764641 [Project 4]
Hedayat AS, Yang M. Optimal and efficient crossover designs for comparing test treatments with a control treatment. Ann Stat. 2005;33:915-943. [Core A]
Hrastinger A, Dietz B, Bauer R, Sagraves R, Mahady G. Is there clinical evidence supporting the use of botanical dietary supplements in children? J Pediatr. 2005;146:311-317. [Core B]
Liu G, Eggler AL, Dietz BM, Mesecar AD, Bolton JL, Pezzuto JM, van Breemen RB. Screening method for the discovery of potential cancer chemoprevention agents based on mass spectrometric detection of alkylated Keap1. Anal Chem. 2005;77:6407-6414. [Project 3]
Mahady GB. Black cohosh (Actaea/Cimicifuga racemosa): review of the clinical data for safety and efficacy in menopausal symptoms. Treat Endocrinol. 2005;4:177-184. [Core B]
Nikolic D, Li Y, Chadwick LR, Pauli GF, van Breemen RB. Metabolism of xanthohumol and isoxanthohumol, prenylated flavonoids from hops (Humulus lupulus L.), by human liver microsomes. J Mass Spectrom. 2005;40:289-299. [Project 1/ Project 3]
Overk CR, Yao P, Chadwick LR, Nikolic D, Sun Y, Cuendet MA, Deng Y, Hedayat AS, Pauli GF, Farnsworth NR, van Breemen RB, Bolton JL. Comparison of the in vitro estrogenic activities of compounds from hops (Humulus lupulus) and red clover (Trifolium pratense). J Agric Food Chem. 2005;53:6246-6253. PMC1815392 [Project 1/ Project 2/ Core B]
Pauli GF, Jaki BU, Lankin DC, Quantitative H NMR: development and potential of a method for natural products analysis. J Nat Prod. 2005, 68:133-149. [Project 1]
Sun Y, Gu C, Liu X, Liang W, Yao P, Bolton JL, van Breemen RB. Ultrafiltration tandem mass spectrometry of estrogens for characterization of structure and affinity for human estrogen receptors. J Am Soc Mass Spectrom. 2005;16:271-279. PMC1780173 [Core C]
Sun Y, Li W, Fitzloff JF, van Breemen RB. Liquid chromatography/electrospray tandem mass spectrometry of terpenoid lactones in Ginkgo biloba. J Mass Spectrom. 2005;40:373-379. PMC1852454 [Core B]
Turner A, Chen SN, Joike MK, Pendland SL, Pauli GF, Farnsworth NR. Inhibition of uropathogenic Escherichia coli by cranberry juice: a new antiadherence assay. J Agric Food Chem. 2005;53:8940-7. [Project 1]
van Breemen RB, Li Y. Caco-2 cell permeability assays to measure drug absorption. Expert Opin Drug Metab Toxicol. 2005, 1:175-185.
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2004 (11)
Booth NL, Nikolic D, van Breemen RB, et al. Confusion regarding anticoagulant coumarins in dietary supplements. Clin Pharmacol Ther. 2004;76:511-516.
Chadwick LR, Nikolic D, Burdette JE, et al. Estrogens and congeners from spent hops (Humulus lupulus). J Nat Prod. 2004;67:2024-2032.
Hedayat AS, Yang M. Universal optimality for selected crossover designs. J Am Statist Assoc. 2004;99:461-466. [Core A]
Hedayat AS, Zhong J, Nie L. Optimal and efficient designs for 2-parameter nonlinear models. J Statist Plan Infer. 2004;124:205-217. [Core A]
Li W, Sun Y, van Breemen RB, Fitzloff JF. Evaluation of major caffeic acid derivatives in echinacea purpurea dietary supplements by HPLC with photodiode array detection and electrospray mass spectrometry. J Liq Chromatogr Rel Technol. 2004;27:2507-2529. [Core C/ Project 3]
Li Y, Grubjesic S, Nikolic D, et al. In vitro assessment of intestinal permeability and hepatic metabolism of 4′-bromoflavone, a promising cancer chemopreventive agent. Xenobiotica. 2004;34:535-547.
Liu J, Burdette JE, Sun Y, et al. Isolation of linoleic acid as an estrogenic compound from the fruits of Vitex agnus-castus L. (chaste-berry). Phytomedicine. 2004;11:18-23.
Mariappan SVS, Cheng X, van Breemen RB, Silks LA, Gupta G. Analysis of GAA/TTC DNA triplexes using nuclear magnetic resonance and electrospray ionization mass spectrometry. Anal Biochem. 2004;334:216-226. [Core C]
Nikolic D, Li Y, Chadwick LR, Grubjesic S, Schwab P, Metz P, van Breemen RB. Metabolism of 8-prenylnaringenin, a potent phytoestrogen from hops (Humulus lupulus), by human liver microsomes. Drug Metab Dispos. 2004;32:272-279. [Core C/ Project 1/ Project 3]
Nikolic D, van Breemen RB. New metabolic pathways for flavonones catalyzed by rat liver microsomes. Drug Metab Dispos. 2004;32:387-397. [Core C/ Project 3]
Piersen CE, Booth NL, Sun Y, Liang W, van Breemen RB, Geller SE, Gu C, Banuvar S, Shulman LP, Bolton JL, Farnsworth NR. Chemical and biological characterization and clinical evaluation of botanical dietary supplements: a phase I red clover extract as a model. Curr Med Chem. 2004;11:1361-1374. [Core A/ Core C/ Project 1/ Project 2/ Project 3/ Project 4]
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2003 (17)
Burdette JE, Liu J, Chen SN, Fabricant DS, Piersen CE, Barker EL, Pezzuto JM, Mesecar A, van Breemen RB, Farnsworth NR, Bolton JL. Black cohosh acts as a mixed competitive ligand and partial agonist of the serotonin receptor. J Agric Food Chem. 2003;51:5661-5670. [Core A/ Core C/ Project 2/ Project 3]
Gafner S, Bergeron C, Batcha LL, Reich J, Arnason JT, Burdette JE, Pezzuto JM, Angerhofer CK. Inhibition of [3H]-LSD binding to 5-HT7 receptors by flavonoids from Scutellaria lateriflora. J Nat Prod. 2003;66:535-537. [Project 2]
Hedayat AS. Adding more observations to saturated D-optimal resolution III two-level factorial designs. Comb Designs. 2003;11:51-77. [Core A]
Hedayat AS, Stufken J. Optimal and efficient crossover designs under different assumptions about the carryover effects. J Biopharm Stat. 2003;13:519-528. [Core A]
Hedayat AS, Yang M. Universal optimality of balanced uniform crossover designs. Ann Stat. 2003;31:978-983. [Core A]
Johnson BM, Qiu SX, Zhang S, Zhang F, Burdette JE, Yu L, Bolton JL, van Breemen RB. Identification of novel electrophilic metabolites of Piper methysticum Forst (Kava). Chem Res Toxicol. 2003;16:733-740. [Core C/ Project 2/ Project 3]
Johnson BM, van Breemen RB. In vitro formation of quinoid metabolites of the dietary supplement Cimicifuga racemosa (black cohosh). Chem Res Toxicol. 2003;16:838-846. [Core C/ Project 3]
Li W, Sun Y, Joseph J, Fitzloff JF, Fong HH, van Breemen RB. p-Hydroxybenzoic acid alkyl esters in Andrographis paniculata herbs, commercial extracts, and formulated products. J Agric Food Chem. 2003;51:524-529. [Core C/ Project 3]
Li W, Sun Y, Liang W, Fitzloff JF, van Breemen RB. Identification of caffeic acid derivatives in Actea racemosa (Cimicifuga racemosa, black cohosh) by liquid chromatography/tandem mass spectrometry. Rapid Commun Mass Spectrom. 2003;17:978-982. [Core C/ Project 3]
Li Y, Shin YG, Yu C, Kosmeda JW, Hirschelman WH, Pezzuto JM, van Breemen RB. Increasing the throughput and productivity of Caco-2 cell permeability assays using liquid chromatography-mass spectrometry: application to resveratrol absorption and metabolism. Comb Chem High Throughput Screen. 2003;6:757-767. [Core C/ Project 2/ Project 3]
Liu X, Zhang F, Liu H, Burdette JE, Li Y, Overk CR, Pisha E, Yao J, van Breemen RB, Swanson SM, Bolton JL. Effect of halogenated substituents on the metabolism and estrogenic effects of the equine estrogen, equilenin. Chem Res Toxicol. 2003;16:741-749. [Project 2/ Project 3]
Lyons MM, Yu C, Toma RB, Cho SY, Reiboldt W, Lee J, van Breemen RB. Resveratrol in raw and baked blueberries and bilberries. J Agric Food Chem. 2003;51:5867-5870. [Core C/ Project 3]
Mahady GB. Is black cohosh estrogenic? Nutr Rev. 2003;61:183-186. [Core B]
Mahady GB, Parrot J, Lee C, Yun GS, Dan A. Botanical dietary supplement use in peri- and postmenopausal women. Menopause. 2003;10:65-72. [Core B]
Piersen CE. Phytoestrogens in botanical dietary supplements: implications for cancer. Integr Cancer Ther. 2003;2:120-138. [Core A]
Yu C, Shin YG, Kosmeder JW, Pezzuto JM, van Breemen RB. Liquid chromatography/tandem mass spectrometric determination of inhibition of human cytochrome P450 isozymes by resveratrol and resveratrol-3-sulfate. Rapid Commun Mass Spectrom. 2003;17:307-313. [Core C/ Project 3]
Zhang HJ, Tan GT, Hoang VD, Hung NV, Cuong NM, Soejarto DD, Pezzuto JM, Fong HH. Natural anti-HIV agents. Part IV. Anti-HIV constituents from Vatica cinerea. J Nat Prod. 2003;66:263-268. [Core B/ Project 2]
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2002 (16)
Afsarinejad K, Hedayat AS. Repeated measurements designs for a model with self and simple mixed carryover effects. J Stat Plan Inference. 2002;106:449-459. [Core A/ Project 4]
Burdette JE, Chen SN, Lu ZZ, Xu H, White BE, Fabricant DS, Liu J, Fong HH, Farnsworh NR, Consatntinou AI, van Breemen RB, Pezzuto JM, Bolton JL. Black cohosh (Cimicifuga racemosa L.) protects against menadione-induced DNA damage through scavenging of reactive oxygen species: bioassay-directed isolation and characterization of active principles. J Agric Food Chem. 2002;50:7022-7028. [Core A/ Core C/ Project 1/ Project 2]
Burdette JE, Liu J, Lantvit D, Lim E, Booth N, Bhat KP, Hedayat S, van Breemen RB, Constantinou AI, Pezzuto JM, Farnsworth NR, Bolton JL. Trifolium pratense (red clover) exhibits estrogenic effects in vivo in ovariectomized Sprague-Dawley rats. J Nutr. 2002;132:27-30. [Core A/ Core C/ Project 1/ Project 2/ Project 3/ Project 4]
Chen SN, Fabricant DS, Lu ZZ, Fong HH, Farnsworth NR. Cimiracemosides I-P, new 9,19-cyclolanostane triterpene glycosides from Cimicifuga racemosa. J Nat Prod. 2002;65:1391-1397. [Project 1]
Chen SN, Fabricant DS, Lu ZZ, Zhang H, Fong HH, Farnsworth NR. Cimiracemates A-D, phenylpropanoid esters from the rhizomes of Cimicifuga racemosa. Phytochemistry. 2002;61:409-413. [Project 1]
Chen SN, Li W, Fabricant DS, Santasiero BD, Mesecar A, Fitzloff JF, Fong HH, Farnsworth NR. Isolation, structure elucidation, and absolute configuration of 26-deoxyactein from Cimicifuga racemosa and clarification of nomenclature associated with 27-deoxyactein. J Nat Prod. 2002;65:601-605. [Project 1/ Project 3]
Hedayat AS, Yan B, M. Pezzuto JMJ. Optimum designs for estimating EDp based on raw optical density data. J. Statist. Plan. Infer. 2002;104:161-174. [Core A/ Project 4]
Johnson BM, Nikolic D, van Breemen RB. Applications of pulsed ultrafiltration-mass spectrometry. Mass Spectrom Rev. 2002;21:76-86. [Core A/ Core C/ Project 3]
Li S-H, Zhang H-J, Qiu S-X, Niu X-M, Santasiero BD, Mesecar AD, Fong HHS, Farnsworth NR, Sun H-D. Vitexlactam A, a novel labdane diterpene lactam from the fruits of Vitex agnus-castus. Tetrahedron Lett. 2002;43:5131-5134. [Project 1 / Project 3]
Li W, Chen S, Fabricant D, Angerhofer CK, Fong HHS, Farnsworth NR, Fitzloff JF. High-performance liquid chromatographic analysis of black cohosh (Cimicifuga racemosa) constituents with in-line evaporative light scattering and photodiode array detection. Anal Chim Acta. 2002;471:61-75. [Project 1]
Li W, Fitzloff JF, Farnsworth NR, Fong HH. Evaluation of commercial Ginkgo biloba dietary supplements for the presence of colchicine by high-performance liquid chromatography. Phytomedicine. 2002;9:442-446. [Project 1]
Li W, Sun Y, Fitzloff JF, van Breemen RB. Evaluation of commercial ginkgo and echinacea dietary supplements for colchicine using liquid chromatography-tandem mass spectrometry. Chem Res Toxicol. 2002;15:1174-1178. [Core A/ Core C/ Project 3]
Lin L, Hedayat AS, Sinha B, Yang M. Statistical methods in assessing agreement. J Am Statist Assoc. 2002;97:257-270. [Core A/ Project 4]
Mahady GB, Fabricant D, Chadwick LR, Dietz B. Black cohosh: an alternative therapy for menopause? Nutr Clin Care. 2002;5:283-289. [Core B/ Project 1/ Project 2]
Shin YG, Bolton JL, van Breemen RB. Screening drugs for metabolic stability using pulsed ultrafiltration mass spectrometry. Comb Chem High Throughput Screen. 2002;5:59-64. [Core C/ Project 3]
Xu H, Fabricant DS, Piersen CE, Bolton JL, Pezzuto JM, Fong HH, Toturn S, Farnsworth NR, Constantinou AI. A preliminary RAPD-PCR analysis of Cimicifuga species and other botanicals used for women’s health. Phytomedicine. 2002;9:757-762. [Project 1/ Project 2]
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2001 (4)
Constantinou AI, Lantvit D, Hawthorne M, Xu X, van Breemen RB, Pezzuto JM. Chemopreventive effects of soy protein and purified soy isoflavones on DMBA-induced mammary tumors in female Sprague-Dawley rats. Nutr Cancer. 2001;41:75-81. [Core A/ Core C/ Project 3]
Johnson BM, Bolton JL, van Breemen RB. Screening botanical extracts for quinoid metabolites. Chem Res Toxicol. 2001;14:1546-1551. [Core A/ Core C/ Project 1/ Project 2]
Liu J, Burdette JE, Xu H, Gu C, van Breemen RB, Bhat KP, Booth N, Constantinou AI, Pezzuto JM, Fong HH, Farnsworth NR, Bolton JL. Evaluation of estrogenic activity of plant extracts for the potential treatment of menopausal symptoms. J Agric Food Chem. 2001;49:2472-2479. [Core A/ Core C/ Project 1/ Project 2/ Project 3]
Shin Y-G, van Breemen RB. Analysis and screening of combinatorial libraries using mass spectrometry. Biopharm Drug Dispos. 2001;22:353-372. [Core A/ Core C/ Project 3]
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2000 (2)
Li W, Gu C, Zhang H, Awang DV, Fitzloff JF, Fong HH, van Breemen RB. Use of high-performance liquid chromatography-tandem mass spectrometry to distinguish Panax ginseng C. A. Meyer (Asian ginseng) and Panax quinquefolius L. (North American ginseng). Anal Chem. 2000;72:5417-5422. [Core A/ Project 3]
Nikolic D, Habibi-Goudarzi S, Corley DG, Gafner S, Pezzuto JM, van Breemen RB. Evaluation of cyclooxygenase-2 inhibitors using pulsed ultrafiltration mass spectrometry. Anal Chem. 2000;72:3853-3859. [Core C/ Project 3]
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1999 (1)
Gu C, Nikolic D, Lai J, Xu X, van Breemen RB. Assays of ligand-human serum albumin binding using pulsed ultrafiltration and liquid chromatography-mass spectrometry. Comb Chem High Throughput Screen. 1999;2:353-359. [Core A/ Core C/ Project 3]